10015 - Desmoplastic Melanoma: An image-intensive histological tour with clinical correlates

Course Directors

Alireza Sepehr, M.D., Harvard Medical School
Anna Harris, M.D., Harvard Medical School
Steven R. Tahan, M.D., Harvard Medical School


Desmoplastic melanoma is an uncommon subtype of melanoma, comprising approximately 1% of cases. It is often difficult to recognize both clinically and histologically, and can assume a wide variety of histologic appearances. Space limitations limit standard Dermatopathology textbooks to a small number of histologic images of this important entity, and the many variations are not represented. This online CME course provides an image-intestive exploration of the histologic appearances of desmoplastic melanoma, with clinical correlation and discussion of its biologic behavior. It reviews the differential diagnosis and keys to accurate recognition, including the application of immunohistochemistry. Finally, management and, specifically, the role of sentinel lymph node biopsy are discussed.


AMA PRA Category 1 Credits™

Opus Medicus designates this Internet enduring material for a maximum of 1.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Maintenance of Certification (MOC) Credits

In addition to AMA PRA Category 1 Credits™, Opus Medicus designates this course for Specialty Board MOC Program Credits:

1.25 ABP CC/MOC Credits1

Accreditation Statement

Opus Medicus is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Tuition Fees

Course & Credits: $32.50

Course Dates

Last Review Date: 10-Jan-2023
Expiration Date: 09-Jan-2026


For Pathologists, Dermatopathologists, and trainees to:

- Readily identify and diagnose with confidence desmoplastic melanoma. desmoplastic malignant melanoma

- Understand the differential diagnosis of desmoplastic melanoma and be able to confidently separate these entities based on histomorphologic and immunohistochemical criteria.

- Learn the molecular genetics of desmoplastic melanoma.

- Learn about the prognosis and treatment of this tumor, including the controversial topic of sentinel lymph node biopsy.


History/background of the desmoplastic melanoma.

Clinical Presentation


Histologic Appearances

Differential Diagnosis


Collagen matrix

Genetics and Molecular

Clinical course

Sentinel Lymph Node Biopsy


Specific topics covered in this AMA PRA Categogy 1 Credit™ online CME course include desmoplasic melanoma diagnosis, desmoplastic melanoma histology, desmoplastic melanoma immunohistochemistry, desmoplastic melanoma simulants, desmoplastic neurotropic melanoma, sclerosing blue nevus, sclerosing Spitz' nevus, sclerosing type-A nevus, lentigo maligna melanoma, SOX2, and malignant melanoma.

American Board of Medical Specialties (ABMS) / Accreditation Council for Graduate Medical Education (ACGME) Competencies

☑  Patient Care (PC)
☑  Medical Knowledge (MK)

Financial Relationship Disclosure and Content Attestation

Drs. Sepehr, Harris and Tahan attest that commercial entities with which they have relationships do not produce health-care related products or services relevant to the content of this course. No other person who has provided content for or who can influence the content of this course has disclosed financial relationships with commercial entities that produce health care-related products or services relevant to the course content.

There has been no commercial support for this course.

Supported Computer Hardware and Software Configurations2

Supported client computing platforms include:

A broadband Internet connection is required (e.g., cable, DSL, and 3G or 4G wireless). The course presentation is automatically scaled to the size of the display, from 800x480 pixels (minimum supported) to 1920x1200 pixels. On some smart phones, viewing courses may be tedious.

Supported browsers include:

Javascript, cookies, and popups must be enabled on your browser (which is the default configuration for most browsers).

1. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.25 CC/MOC credits for the American Board of Pathology (ABP) Continuing Certification (CC) / Maintenance of Certification (MOC) Program, in addition to AMA PRA Category 1 Credits™. Participants will earn CC/MOC credits equivalent to the amount of AMA PRA Category 1 credits claimed for the activity. Immediately upon course completion, Opus Medicus will submit participant completion information to ACCME for the purpose of granting ABP CC/MOC credit.

2. The course may also be viewable on other client computing platforms that comply with Internet standards. If you experience technical problems that prevent you from viewing the course, we will promptly issue a full refund upon request.