10036 - Origins of Ovarian Epithelial Cancer: Theoretical and Practical Aspects

Course Director

Christopher P. Crum, M.D., Harvard Medical School


This course will review evidence to support current concepts of the origin and development of ovarian epithelial carcinoma. It will discuss practical applications of these concepts to diagnosis, staging, and treatment.


AMA PRA Category 1 Credits™

Opus Medicus designates this Internet enduring material for a maximum of 1.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Maintenance of Certification (MOC) Credits

In addition to AMA PRA Category 1 Credits™, Opus Medicus designates this course for Specialty Board MOC Program Credits:

1.25 ABP CC/MOC Credits1

Accreditation Statement

Opus Medicus is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Tuition Fees

Course & Credits: $32.50

Course Dates

Last Review Date: 19-Sep-2019
Expiration Date: 18-Sep-2022


1. To update pathologists, oncologists, gynecologists and trainees on current concepts of the origins of ovarian and fallopian tube epithelial carcinoma.

2. To discuss implications for clinical practice and surgical pathology.


1. Review of ovarian serous carcinoma.

2. BRCA as a model for early ovarian cancer.

3. Sectioning of the fallopian tube: the SEE-FIM Protocol.

4. Early serous carcinoma in the fimbria.

5. Serous tubal intraepithelial carcinoma (STIC).

6. Early versus late STICs.

7. Ovarian serous carcinoma associated with tubal intraepithelial carcinoma (TIC).

8. Tubal intraepithelial carcinoma associated with primary peritoneal serous carcinoma.

9. Pathways for the development of ovarian serous carcinoma

10. p53 signature.

11. Proliferative/expansile p53 signature .

12. Tubal p53 Signature as a precursor to pelvic serous carcinoma.

13. Li Fraumeni Syndrome.

14. Secretory cell outgrowths in the fallopian tube (SCOUTs).

15. Practice-relevant issues.

16. Approach to tubal intraepithelial carcinoma.

Specific topics covered in this AMA PRA Categogy 1 Credit™ online CME course include ovarian serous carcinoma, BRCA, SEE-FIM Protocol, fallopian tube carcinoma, Serous tubal intraepithelial carcinoma (STIC), tubal intraepithelial carcinoma (TIC), primary peritoneal serous carcinoma, p53 signature, Li Fraumeni syndrome, and secretory cell outgrowths in the fallopian tube (SCOUTs).

American Board of Medical Specialties (ABMS) / Accreditation Council for Graduate Medical Education (ACGME) Competencies

☑  Patient Care (PC)
☑  Medical Knowledge (MK)
☑  Practice-Based Learning (PBL)

Financial Relationship Disclosure and Content Attestation

Dr. Christopher P. Crum, Course Director, attests that he has no financial relationships with a commercial entity producing health-care related products and/or services. Dr. Steven R. Tahan, Education Committee Chair, attests that commercial entities with which he has relationships do not produce health-care related products or services relevant to the content of this course. No other person who has provided content for or who can influence the content of this course has disclosed financial relationships with commercial entities that produce health care-related products or services relevant to the course content.

There has been no commercial support for this course.

Supported Computer Hardware and Software Configurations2

Supported client computing platforms include:

A broadband Internet connection is required (e.g., cable, DSL, and 3G or 4G wireless). The course presentation is automatically scaled to the size of the display, from 800x480 pixels (minimum supported) to 1920x1200 pixels. On some smart phones, viewing courses may be tedious.

Supported browsers include:

Javascript, cookies, and popups must be enabled on your browser (which is the default configuration for most browsers).

1. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.25 CC/MOC credits for the American Board of Pathology (ABP) Continuing Certification (CC) / Maintenance of Certification (MOC) Program, in addition to AMA PRA Category 1 Credits™. Participants will earn CC/MOC credits equivalent to the amount of AMA PRA Category 1 credits claimed for the activity. Immediately upon course completion, Opus Medicus will submit participant completion information to ACCME for the purpose of granting ABP CC/MOC credit.

2. The course may also be viewable on other client computing platforms that comply with Internet standards. If you experience technical problems that prevent you from viewing the course, we will promptly issue a full refund upon request.