10037 - New Precursors of the Female Genital Tract: Case Studies

Course Director

Christopher P. Crum, M.D., Harvard Medical School


This course uses a case-based approach to illustrate precursor lesions of the female genital tract that have recently been elucidated and refined. It highlights recently recognized paradigms of early neoplasia and reviews the utility of immunohistochemical stains.


AMA PRA Category 1 Credits™

Opus Medicus designates this Internet enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Maintenance of Certification (MOC) Credits

In addition to AMA PRA Category 1 Credits™, Opus Medicus designates this course for Specialty Board MOC Program Credits:

1.5 ABP CC/MOC Credits1

Accreditation Statement

Opus Medicus is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Tuition Fees

Course & Credits: $39.00

Course Dates

Last Review Date: 19-Sep-2021
Expiration Date: 18-Sep-2024


1. To illustrate the concept of differentiated vulvar intraepithelial neoplasia (VIN) and illustrate complicating elements in biopsy interpretation.

2. To discuss the interpretation of cervical low grade squamous intraepithelial neoplasia (SIL) in immature metaplasia and review the value of P16 immunostaining.

3. To illustrate the role of reserve cells in the development and pathology of endocervical microglandular change.

4. To illustrate the challenges often encountered in interpretation of endometrial intraepithelial neoplasia in endometrial polyps.

5. To review findings in a salpingectomy from a woman with a serous cystadenoma .


1. Differentiated VIN versus classic (usual) VIN with lichen simplex chronicus.

2. Immature squamous metaplasia of the cervix and low grade SIL.

3. Endocervical microglandular change.

4. Endometrial polyps and endometrial intraepithelial neoplasia.

5. Fallopian tube epithelial atypia associated with serous cystadenoma

Specific topics covered in this AMA PRA Categogy 1 Credit™ online CME course include vulvar intraepithelial neoplasia, differentiated VIN, classic (usual) VIN, cervical immature squamous metaplasia, squamous intraepithelial neoplasia, endocervical microglandular change, reserve cells, endometrial polyp, endometrial intraepithelial neoplasia, p53 signature Proliferative (expansile) signature, tubal intraepithelial carcinoma, and tubal epithelial atypia.

American Board of Medical Specialties (ABMS) / Accreditation Council for Graduate Medical Education (ACGME) Competencies

☑  Patient Care (PC)
☑  Medical Knowledge (MK)
☑  Practice-Based Learning (PBL)

Financial Relationship Disclosure and Content Attestation

Dr. Christopher P. Crum, Course Director, attests that he has no financial relationships with a commercial entity producing health-care related products and/or services. Dr. Steven R. Tahan, Education Committee Chair, attests that commercial entities with which he has relationships do not produce health-care related products or services relevant to the content of this course. No other person who has provided content for or who can influence the content of this course has disclosed financial relationships with commercial entities that produce health care-related products or services relevant to the course content.

There has been no commercial support for this course.

Supported Computer Hardware and Software Configurations2

Supported client computing platforms include:

A broadband Internet connection is required (e.g., cable, DSL, and 3G or 4G wireless). The course presentation is automatically scaled to the size of the display, from 800x480 pixels (minimum supported) to 1920x1200 pixels. On some smart phones, viewing courses may be tedious.

Supported browsers include:

Javascript, cookies, and popups must be enabled on your browser (which is the default configuration for most browsers).

1. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.5 CC/MOC credits for the American Board of Pathology (ABP) Continuing Certification (CC) / Maintenance of Certification (MOC) Program, in addition to AMA PRA Category 1 Credits™. Participants will earn CC/MOC credits equivalent to the amount of AMA PRA Category 1 credits claimed for the activity. Immediately upon course completion, Opus Medicus will submit participant completion information to ACCME for the purpose of granting ABP CC/MOC credit.

2. The course may also be viewable on other client computing platforms that comply with Internet standards. If you experience technical problems that prevent you from viewing the course, we will promptly issue a full refund upon request.