10057 - LAST Diagnostic Terminology for HPV-Related Lesion of the Lower Anal-genital Tract and Application to Non-classical Lesions

Course Director

Jonathan Hecht, M.D., Ph.D., Harvard Medical School


This course addresses the issues related to applying the recomendations of the recent consensus conference for diagnostic terminology for HPV related lesion of the lower anal-genital tract (LAST).


AMA PRA Category 1 Credits™

Opus Medicus designates this Internet enduring material for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Maintenance of Certification (MOC) Credits

In addition to AMA PRA Category 1 Credits™, Opus Medicus designates this course for Specialty Board MOC Program Credits:

1.0 ABP CC/MOC Credits1

Accreditation Statement

Opus Medicus is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Tuition Fees

Course & Credits: $26.00

Course Dates

Last Review Date: 14-Aug-2022
Expiration Date: 13-Aug-2025


For Pathologists to learn:

1. Recommendations from the LAST conference for terminology of lower ano-genital squamous lesions.

2. Principles and pratice application of these recommendations.

3. Biomarker use and understand their limitations for diagnosis of HPV-associated preinvasive lesions of the lower ano-genital tract.

4. Identification and criteria for superficially invasive squamous cell carcinoma by anatomic site

5. Problem areas.


LAST Project and Terminology

Problem case #1: Focal HSIL adjacent to condyloma

Biomarker Uses

Mimics of HSIL

Cytology-Biopsy Discrepancy/QA

Superficially Invasive Squamous Cell Carcinomas (SISCCA)

SISCCA Depth of Invasion

Other Problem Cases

Specific topics covered in this AMA PRA Categogy 1 Credit™ online CME course include LAST, Anal SIL, Ano-genital HPV lesions, Ano-genital squamous cell carcinoma, p16, squamous intraepithelial lesion, and HSIL.

American Board of Medical Specialties (ABMS) / Accreditation Council for Graduate Medical Education (ACGME) Competencies

☑  Patient Care (PC)
☑  Medical Knowledge (MK)
☑  Practice-Based Learning (PBL)

Financial Relationship Disclosure and Content Attestation

Dr. Jonathan L. Hecht attests that he has no financial relationships with a commercial entity producing health-care related products and/or services. Dr. Steven R. Tahan, Education Committee Chair, attests that commercial entities with which he has relationships do not produce health-care related products or services relevant to the content of this course. No other person who has provided content for or who can influence the content of this course has disclosed financial relationships with commercial entities that produce health care-related products or services relevant to the course content.

There has been no commercial support for this course.

Supported Computer Hardware and Software Configurations2

Supported client computing platforms include:

A broadband Internet connection is required (e.g., cable, DSL, and 3G or 4G wireless). The course presentation is automatically scaled to the size of the display, from 800x480 pixels (minimum supported) to 1920x1200 pixels. On some smart phones, viewing courses may be tedious.

Supported browsers include:

Javascript, cookies, and popups must be enabled on your browser (which is the default configuration for most browsers).

1. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 CC/MOC credits for the American Board of Pathology (ABP) Continuing Certification (CC) / Maintenance of Certification (MOC) Program, in addition to AMA PRA Category 1 Credits™. Participants will earn CC/MOC credits equivalent to the amount of AMA PRA Category 1 credits claimed for the activity. Immediately upon course completion, Opus Medicus will submit participant completion information to ACCME for the purpose of granting ABP CC/MOC credit.

2. The course may also be viewable on other client computing platforms that comply with Internet standards. If you experience technical problems that prevent you from viewing the course, we will promptly issue a full refund upon request.