10111 - Dermatopathology, then and now - Have we traveled?

Course Director

Meera Mahalingam, M.D., Boston University School of Medicine


This course reviews the evolving understanding of Dermatopathology using examples of melanocytic "dysplasia" and sebaceous neoplasia. It specifically reviews the concept of melanocytic "dysplasia" and pathways of evolution to malignant melanoma. It reviews the role of activating BRAF mutations in senescence and the development of malignant melanoma, the role of insulin-like growth factor binding protein 7, RAF and RAS mutations and their relation to sun exposure. The course also reviews the role of mismatch repair gene mutations in sebaceous neoplasia and Muir-Torre syndrome.


AMA PRA Category 1 Credits™

Opus Medicus designates this Internet enduring material for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Maintenance of Certification (MOC) Credits

In addition to AMA PRA Category 1 Credits™, Opus Medicus designates this course for Specialty Board MOC Program Credits:

1.0 ABP SAM for MOC/CC Credits1

Accreditation Statement

Opus Medicus is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Tuition Fees

Course & Credits: $24.00

Course Dates

Last Review Date: 20-Nov-2017
Expiration Date: 19-Nov-2020


After taking this course participants will have improved understanding of advances in understanding the molecular basis of malignant melanoma and sebaceous neoplasia.


1. Historical review of the early subspecialization of the field of Dermatopathology.

2. Molecular advances in the concept of "dysplasia" as applied to melanocytic lesions.

3. Muir-Torre syndrome.

4. Mismatch repair proteiins.

5. Microsatellite stability/instability.

6. Mutations in mismatch repair gene MSH6 and cancer susceptibility.

7. Molecular basis of sebaceous neoplasms.

Specific topics covered in this AMA PRA Categogy 1 Credit™ online CME course include Dysplastic nevus, BRAF, melanoma, Muir-Torre, mismatch repair, sebaceous, and Lynch syndrome..

American Board of Medical Specialties (ABMS) / Accreditation Council for Graduate Medical Education (ACGME) Competencies

☑  Patient Care (PC)
☑  Medical Knowledge (MK)
☑  Systems-Based Practice (SBP)
☑  Practice-Based Learning (PBL)

Financial Relationship Disclosure and Content Attestation

Dr. Meera Mahalingam attests that she has no financial relationships with a commercial entity producing healthcare-related products and/or services. Dr. Steven R. Tahan, Education Committee Chair, attests that commercial entities with which he has relationships do not produce healthcare-related products or services relevant to the content of this course. No other person who has provided content for or who can influence the content of this course has disclosed financial relationships with commercial entities that produce healthcare-related products or services relevant to the course content.

There has been no commercial support for this course.

Supported Computer Hardware and Software Configurations2

Supported client computing platforms include:

A broadband Internet connection is required (e.g., cable, DSL, and 3G or 4G wireless). The course presentation is automatically scaled to the size of the display, from 800x480 pixels (minimum supported) to 1920x1200 pixels. On some smart phones, viewing courses may be tedious.

Supported browsers include:

Javascript, cookies, and popups must be enabled on your browser (which is the default configuration for most browsers).

1. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 Self Assessment Module (SAM) Credits in the American Board of Pathology (ABP) Maintenance of Certification (MOC) / Continuing Certification (CC) Program, in addition to AMA PRA Category 1 Credits™. Participants will earn SAM for MOC/CC credits equivalent to the amount of AMA PRA Category 1 credits claimed for the activity. Immediately upon course completion, Opus Medicus will submit participant completion information to ACCME for the purpose of granting ABP MOC/CC credit.

2. The course may also be viewable on other client computing platforms that comply with Internet standards. If you experience technical problems that prevent you from viewing the course, we will promptly issue a full refund upon request.