10120 - The inflammation highway: metabolism accelerates inflammatory traffic in obesity

Course Directors

Amy R. Johnson, Ph.D., University of North Carolina
J. Justin Milner, Ph.D., University of North Carolina
Liza Makowski, Ph.D., University of North Carolina


Obesity is a state of low-grade, chronic inflammation that promotes the development of insulin resistance and diabetes. This course reviews the complex relationship between obesity, insulin resistance/diabetes, and inflammation. It focuses specifically on how the obese adipose microenvironment can promote immune cell influx and sustain damaging inflammation that can lead to the onset of insulin resistance and diabetes. The course addresses how substrate metabolism may regulate the immune response and discusses how fuel uptake and metabolism may be a targetable approach to limit or abrogate obesity-induced inflammation.


AMA PRA Category 1 Credits™

Opus Medicus designates this Internet enduring material for a maximum of 2.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Maintenance of Certification (MOC) Credits

In addition to AMA PRA Category 1 Credits™, Opus Medicus designates this course for Specialty Board MOC Program Credits:

2.0 ABIM MOC Points1

Accreditation Statement

Opus Medicus is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Tuition Fees

Course & Credits: $52.00

Course Dates

Last Review Date: 30-Aug-2020
Expiration Date: 30-Aug-2023


After completing this course, participants will understand:

1. Link between obesity-associated inflammation and insulin resistance.

2. The adipose microenvironment.

3. Mechanisms of inflammatory activation.

4. Links between obesity and chronic disease, liver disease, and infection susceptibility.


1. Obesity-Associated Inflammation and Insulin Resistance

2. Adipose Microenvironment

3. Mechanisms of Inflammatory Activation

4. Links between Obesity, Inflammation and Human Health

American Board of Medical Specialties (ABMS) / Accreditation Council for Graduate Medical Education (ACGME) Competencies

☑  Patient Care (PC)
☑  Medical Knowledge (MK)

Financial Relationship Disclosure and Content Attestation

Drs. Amy R. Johnson, J. Justin Milner, and Liza Makowski attest that they have no financial relationships with commercial entities offering healthcare related products and/or services. Dr. Steven R. Tahan, Education Committee Chair, attests that commercial entities with which he has relationships do not offer healthcare related products or services relevant to the content of this course. No other person who has provided content for or who can influence the content of this course has disclosed financial relationships with commercial entities that offer healthcare-related products or services relevant to the course content.

There has been no commercial support for this course.

Supported Computer Hardware and Software Configurations2

Supported client computing platforms include:

A broadband Internet connection is required (e.g., cable, DSL, and 3G or 4G wireless). The course presentation is automatically scaled to the size of the display, from 800x480 pixels (minimum supported) to 1920x1200 pixels. On some smart phones, viewing courses may be tedious.

Supported browsers include:

Javascript, cookies, and popups must be enabled on your browser (which is the default configuration for most browsers).

1. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 2.0 MOC points for the American Board of Internal Medicine (ABIM) Maintenance of Certification (MOC) Program, in addition to AMA PRA Category 1 Credits™. Participants will earn MOC points equivalent to the amount of AMA PRA Category 1 credits claimed for the activity. Immediately upon course completion, Opus Medicus will submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

2. The course may also be viewable on other client computing platforms that comply with Internet standards. If you experience technical problems that prevent you from viewing the course, we will promptly issue a full refund upon request.