10126 - Malignant Mesothelioma: A Historical Account and a Personal Perspective

Course Director

Christopher N. Otis, M.D., Tufts University School of Medicine


This course reviews the history of the diagnosis of mesothelioma, reviews problems concerning the cytologic diagnosis of mesothelioma, and provides an update on the use of immunohistochemical stains in differentiating benign from malignant mesothelial cells in effusions.


AMA PRA Category 1 Credits™

Opus Medicus designates this Internet enduring material for a maximum of 1.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Maintenance of Certification (MOC) Credits

In addition to AMA PRA Category 1 Credits™, Opus Medicus designates this course for Specialty Board MOC Program Credits:

1.75 ABP CC/MOC Credits1

Accreditation Statement

Opus Medicus is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Tuition Fees

Course & Credits: $45.50

Course Dates

Last Review Date: 15-May-2022
Expiration Date: 14-May-2025


After taking this course, participants will:

1. Increase their familiarity with the history of the diagnosis of mesothelioma.

2. Be able to construct an immunohistochemical panel for the identification of mesothelioma.

3. Be familiar with controversies concerning the cytologic diagnosis of mesothelioma.

4. Be familiar with the histologic types of mesothelioma.

5. Understand the role of immunohistochemistry in differentiating benign from malignant mesothelial cells in effusions.


1. History of the recognition and diagnosis of mesothelioma.

2. Risk factors and clinical presentation of mesothelioma.

3. Histopathology of mesothelioma

4. Immunohistochemical profile of mesothelioma.

5. "Atypical mesothelial cells" in effusions.

6. Morphologic features that distinguish mesothelioma from benign mesothelial cells.

7. Glucose transporter proteins.

8. Glut-1, EMA, and desmin expression in distinguishing benign from malignant mesothelial cells in effusions.

Specific topics covered in this AMA PRA Categogy 1 Credit™ online CME course include mesothelioma, Glut-1, and effusion cytologic.

American Board of Medical Specialties (ABMS) / Accreditation Council for Graduate Medical Education (ACGME) Competencies

☑  Patient Care (PC)
☑  Medical Knowledge (MK)
☑  Practice-Based Learning (PBL)

Financial Relationship Disclosure and Content Attestation

Dr. Christopher N. Otis attests that he has no financial relationships with a commercial entity offering healthcare related products and/or services. Dr. Steven R. Tahan, Education Committee Chair, attests that commercial entities with which he has relationships do not offer healthcare related products or services relevant to the content of this course. No other person who has provided content for or who can influence the content of this course has disclosed financial relationships with commercial entities that offer healthcare-related products or services relevant to the course content.

There has been no commercial support for this course.

Supported Computer Hardware and Software Configurations2

Supported client computing platforms include:

A broadband Internet connection is required (e.g., cable, DSL, and 3G or 4G wireless). The course presentation is automatically scaled to the size of the display, from 800x480 pixels (minimum supported) to 1920x1200 pixels. On some smart phones, viewing courses may be tedious.

Supported browsers include:

Javascript, cookies, and popups must be enabled on your browser (which is the default configuration for most browsers).

1. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.75 CC/MOC credits for the American Board of Pathology (ABP) Continuing Certification (CC) / Maintenance of Certification (MOC) Program, in addition to AMA PRA Category 1 Credits™. Participants will earn CC/MOC credits equivalent to the amount of AMA PRA Category 1 credits claimed for the activity. Immediately upon course completion, Opus Medicus will submit participant completion information to ACCME for the purpose of granting ABP CC/MOC credit.

2. The course may also be viewable on other client computing platforms that comply with Internet standards. If you experience technical problems that prevent you from viewing the course, we will promptly issue a full refund upon request.