10129 - Positron emission tomography imaging of prostate cancer

Course Directors

Weibo Cai, Ph.D., University of Wisconsin
Hao Hong, Ph.D., University of Wisconsin
Jiangtao Sun, Ph.D., Changzhou University, China
Yin Zhang, Ph.D., Johns Hopkins University


Prostate cancer (PCa) is the second leading cause of cancer death among men in the United States. Positron emission tomography (PET), a non-invasive, sensitive, and quantitative imaging technique, can facilitate personalized management of PCa patients. There are two critical needs for PET imaging of PCa, early detection of primary lesions and accurate imaging of PCa bone metastasis, the predominant cause of death in PCa. Since the most widely used PET tracer in the clinic, 18F-fluoro-2-deoxy-2-D-glucose (18F-FDG), does not meet these needs, a wide variety of PET tracers have been developed for PCa imaging which span an enormous size range from small molecules to intact antibodies.

This course covers PET tracers for PCa imaging, including small molecule-based, radiolabeled amino acid derivatives, peptide-based tracers, and radiolabeled antibodies and antibody fragments. The course also identifies future directions for the development of novel PET tracers for PCa imaging, which may eventually lead to personalized management of PCa patients.


Opus Medicus designates this Internet enduring material for a maximum of 2.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Accreditation Statement

Opus Medicus is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Tuition Fees

Course & Credits: $52.00

Course Dates

Last Review Date: 15-Jun-2018
Expiration Date: 14-Jun-2021


After completing this course, participants will understand:

1. Available PET tracers for prostate cancer imaging.

2. Future directions for the development of novel PET tracers for PCa imaging.


1. Small molecule-based PET tracers for PCa imaging

2. Radiolabeled amino acid derivatives for PET imaging of PCa

3. Radiolabeled peptides for PCa imaging

4. Radiolabeled antibodies for PET imaging of PCa

5. Radiolabeled antibody fragments for PET imaging of PCa

6. Conclusion and future perspectives

Specific topics covered in this AMA PRA Categogy 1 Credit™ online CME course include 11C-methionine, radiolabeled leucine analogs, radiolabeled tryptophan analog, radiolabeled cysteine analogs, bombesin (BBN) peptides, 64Cu-labeled BBN analogs, 18F-labeled BBN analogs, and 68Ga-labeled BBN analogs.

American Board of Medical Specialties (ABMS) / Accreditation Council for Graduate Medical Education (ACGME) Competencies

☑  Patient Care (PC)
☑  Medical Knowledge (MK)

Financial Relationship Disclosure and Content Attestation

Drs. Weibo Cai, Hao Hong, Jiangtao Sun, and Yin Zhang attest that they have no financial relationships with commercial entities offering healthcare related products and/or services. Dr. Steven R. Tahan, Education Committee Chair, attests that commercial entities with which he has relationships do not offer healthcare related products or services relevant to the content of this course. No other person who has provided content for or who can influence the content of this course has disclosed financial relationships with commercial entities that offer healthcare-related products or services relevant to the course content.

There has been no commercial support for this course.

Supported Computer Hardware and Software Configurations1

Supported client computing platforms include:

A broadband Internet connection is required (e.g., cable, DSL, and 3G or 4G wireless). The course presentation is automatically scaled to the size of the display, from 800x480 pixels (minimum supported) to 1920x1200 pixels. On some smart phones, viewing courses may be tedious.

Supported browsers include:

Javascript, cookies, and popups must be enabled on your browser (which is the default configuration for most browsers).

1. The course may also be viewable on other client computing platforms that comply with Internet standards. If you experience technical problems that prevent you from viewing the course, we will promptly issue a full refund upon request.