10159 - Placental Implantation: A Morphologic Review

Course Director

Jonathan Hecht, M.D., Ph.D., Harvard Medical School


This course describes the normal development of the placenta from the unique perspective of the implantation site. Diseases that affect invasion of maternal tissue by fetal trophoblast, a major cause of morbidity during pregnancy, will be discussed including:

  •  Ectopic (tubal) pregnancy

  •  Invasive implantation (Placenta accreta, increta, percreta)

  •  Vascular abnormalities of implantation (Growth restriction, pre-eclampsia)

  •  Tumors of intermediate trophoblast:

      –  Exaggerated placental site (EPS)

      –  Placental site trophoblastic tumor (PSTT)

      –  Placental site nodule (PSN)

      –  Epithelioid trophoblastic tumor (ETT)


AMA PRA Category 1 Credits™

Opus Medicus designates this Internet enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Maintenance of Certification (MOC) Credits

In addition to AMA PRA Category 1 Credits™, Opus Medicus designates this course for Specialty Board MOC Program Credits:

1.5 ABP CC/MOC Credits1

Accreditation Statement

Opus Medicus is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Tuition Fees

Course & Credits: $39.00

Course Dates

Last Review Date: 12-Mar-2020
Expiration Date: 12-Mar-2023


After taking this course, participants will be able to:

1. Describe the morphologic changes in the placental bed during normal pregnancy

2. Define subtypes of non-villous trophoblast and their functions in the placental bed

3. Describe major diseases that affect or are caused by abnormalities of implantation


1. Ectopic (tubal) pregnancy

2. Invasive implantation (Placenta accreta, increta, percreta)

3. Vascular abnormalities of implantation (Growth restriction, pre-eclampsia)

4. Tumors of intermediate trophoblast:

   •  Exaggerated placental site (EPS)

   •  Placental site trophoblastic tumor (PSTT)

   •  Placental site nodule (PSN)

   •  Epithelioid trophoblastic tumor (ETT)

Specific topics covered in this AMA PRA Categogy 1 Credit™ online CME course include Ectopic pregnancy, implantation, accreta, increta, percreta, growth restriction, preeclampsia, trophoblast, exaggerated placental site, placental site trophoblastic tumor, and placental site noduleepithelioid trophoblastic tumor.

American Board of Medical Specialties (ABMS) / Accreditation Council for Graduate Medical Education (ACGME) Competencies

☑  Patient Care (PC)
☑  Medical Knowledge (MK)

Financial Relationship Disclosure and Content Attestation

Dr. Jonathan Hecht attests that he has no financial relationships with a commercial entity offering healthcare related products and/or services. Dr. Steven R. Tahan, Education Committee Chair, attests that commercial entities with which he has relationships do not offer healthcare-related products or services relevant to the content of this course. No other person who has provided content for or who can influence the content of this course has disclosed financial relationships with commercial entities that offer healthcare-related products or services relevant to the course content.

There has been no commercial support for this course.

Supported Computer Hardware and Software Configurations2

Supported client computing platforms include:

A broadband Internet connection is required (e.g., cable, DSL, and 3G or 4G wireless). The course presentation is automatically scaled to the size of the display, from 800x480 pixels (minimum supported) to 1920x1200 pixels. On some smart phones, viewing courses may be tedious.

Supported browsers include:

Javascript, cookies, and popups must be enabled on your browser (which is the default configuration for most browsers).

1. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.5 CC/MOC credits for the American Board of Pathology (ABP) Continuing Certification (CC) / Maintenance of Certification (MOC) Program, in addition to AMA PRA Category 1 Credits™. Participants will earn CC/MOC credits equivalent to the amount of AMA PRA Category 1 credits claimed for the activity. Immediately upon course completion, Opus Medicus will submit participant completion information to ACCME for the purpose of granting ABP CC/MOC credit.

2. The course may also be viewable on other client computing platforms that comply with Internet standards. If you experience technical problems that prevent you from viewing the course, we will promptly issue a full refund upon request.