10160 - The Evolution of Diagnostic Immunohistochemistry for Soft Tissue Tumors

Course Director

Jason L. Hornick, M.D., Ph.D., Harvard Medical School


This course will explain the evolution of immunohistochemistry for soft tissue tumors from lineage determination to protein correlates of molecular genetic alterations and explain the application of recently developed novel markers.


AMA PRA Category 1 Credits™

Opus Medicus designates this Internet enduring material for a maximum of 1.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Maintenance of Certification (MOC) Credits

In addition to AMA PRA Category 1 Credits™, Opus Medicus designates this course for Specialty Board MOC Program Credits:

1.75 ABP CC/MOC Credits1

Accreditation Statement

Opus Medicus is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Tuition Fees

Course & Credits: $45.50

Course Dates

Last Review Date: 09-May-2020
Expiration Date: 09-May-2023


Physicians completing this course will have an understanding of:

1. The limitations of conventional diagnostic markers for soft tissue tumors.

2. Recently developed diagnostic immunohistochemical markers for soft tissue tumors.

3. The application of these markers for differential diagnosis.


1. Soft tissue tumor pathology

2. Molecular genetic alterations

3. Immunohistochemistry

4. Lineage-Restricted Transcription Factors

5. SMARCB1A (INI1) and neoplasia

6. Polycomb Repressive Complex

7. Immunohistochemistry for H3K27me3 in human neoplasms

8. Succinate Dehydrogenase Mutations and Tumorigenesis

9. Protein Products of Gene Fusions: WT1, TFE3, ALK and ROS1, STAT6, CCNB3, CAMTA1

10. MUC4 in Low-Grade Fibromyxoid Sarcoma

Specific topics covered in this AMA PRA Categogy 1 Credit™ online CME course include SMARCB1A, INI1, polycomb repressive complex, H3K27me3, succinate dehydrogenase, ALK, STAT6, CAMTA1, MUC4, and low-grade fibromyxoid sarcoma.

American Board of Medical Specialties (ABMS) / Accreditation Council for Graduate Medical Education (ACGME) Competencies

☑  Patient Care (PC)
☑  Medical Knowledge (MK)

Financial Relationship Disclosure and Content Attestation

Dr. Jason Hornick attests that he has no financial relationships with a commercial entity offering healthcare related products and/or services. Dr. Steven R. Tahan, Education Committee Chair, attests that commercial entities with which he has relationships do not offer healthcare-related products or services relevant to the content of this course. No other person who has provided content for or who can influence the content of this course has disclosed financial relationships with commercial entities that offer healthcare-related products or services relevant to the course content.

There has been no commercial support for this course.

Supported Computer Hardware and Software Configurations2

Supported client computing platforms include:

A broadband Internet connection is required (e.g., cable, DSL, and 3G or 4G wireless). The course presentation is automatically scaled to the size of the display, from 800x480 pixels (minimum supported) to 1920x1200 pixels. On some smart phones, viewing courses may be tedious.

Supported browsers include:

Javascript, cookies, and popups must be enabled on your browser (which is the default configuration for most browsers).

1. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.75 CC/MOC credits for the American Board of Pathology (ABP) Continuing Certification (CC) / Maintenance of Certification (MOC) Program, in addition to AMA PRA Category 1 Credits™. Participants will earn CC/MOC credits equivalent to the amount of AMA PRA Category 1 credits claimed for the activity. Immediately upon course completion, Opus Medicus will submit participant completion information to ACCME for the purpose of granting ABP CC/MOC credit.

2. The course may also be viewable on other client computing platforms that comply with Internet standards. If you experience technical problems that prevent you from viewing the course, we will promptly issue a full refund upon request.