10168 - Biomarkers in Diagnostic Genitourinary Pathology

Course Director

Michelle Hirsch, M.D., Ph.D., Harvard Medical School


This course employs a case-based approach to illustrate the application of new biomarkers as an adjunct to histomorphologic features for diagnosing renal infiltrative tumors, bladder urothelial carcinoma, and testicular germ cell tumors.


AMA PRA Category 1 Credits™

Opus Medicus designates this Internet enduring material for a maximum of 1.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Maintenance of Certification (MOC) Credits

In addition to AMA PRA Category 1 Credits™, Opus Medicus designates this course for Specialty Board MOC Program Credits:

1.25 ABP CC/MOC Credits1

Accreditation Statement

Opus Medicus is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Tuition Fees

Course & Credits: $32.50

Course Dates

Last Review Date: 20-Nov-2020
Expiration Date: 20-Nov-2023


After completing this course, physicians are expected to improve their understanding of:

1. How to approach differential diagnoses in GU pathology practically based on H&E evaluation.

2. How a practical and select panel of biomarkers can be used to confirm one's H&E impression.

3. Differential diagnoses and how biomarkers can help to confirm or exclude diagnostic considerations in GU pathology.


1. Primary lymphoma of the kidney.

2. Differential Diagnosis of infiltrative renal neoplasms.

3. Diagnostic significance of PAX8 positivity.

4. Flat lesions of the bladder urothelium.

5. Papillary urothelial carcinoma.

6. Urothelial carcinoma in situ.

7. Stathmin1 and its diagnostic significance.

8. Germ cell tumors of the testis.

9. New biomarkers for embryonal versus choriocarcnoma.

10. GATA3 expression in germ cell tumors.

Specific topics covered in this AMA PRA Categogy 1 Credit™ online CME course include kidney lymphoma, bladder urotheliail carcinoma, testicular germ cell tumor, PAX8, GATA3, and Stathmin1.

American Board of Medical Specialties (ABMS) / Accreditation Council for Graduate Medical Education (ACGME) Competencies

☑  Patient Care (PC)
☑  Medical Knowledge (MK)

Financial Relationship Disclosure and Content Attestation

Dr. Michelle Hirsch attests that she has no financial relationships with a commercial entity offering healthcare related products and/or services. Dr. Steven R. Tahan, Education Committee Chair, attests that commercial entities with which he has relationships do not offer healthcare-related products or services relevant to the content of this course. No other person who has provided content for or who can influence the content of this course has disclosed financial relationships with commercial entities that offer healthcare-related products or services relevant to the course content.

There has been no commercial support for this course.

Supported Computer Hardware and Software Configurations2

Supported client computing platforms include:

A broadband Internet connection is required (e.g., cable, DSL, and 3G or 4G wireless). The course presentation is automatically scaled to the size of the display, from 800x480 pixels (minimum supported) to 1920x1200 pixels. On some smart phones, viewing courses may be tedious.

Supported browsers include:

Javascript, cookies, and popups must be enabled on your browser (which is the default configuration for most browsers).

1. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.25 CC/MOC credits for the American Board of Pathology (ABP) Continuing Certification (CC) / Maintenance of Certification (MOC) Program, in addition to AMA PRA Category 1 Credits™. Participants will earn CC/MOC credits equivalent to the amount of AMA PRA Category 1 credits claimed for the activity. Immediately upon course completion, Opus Medicus will submit participant completion information to ACCME for the purpose of granting ABP CC/MOC credit.

2. The course may also be viewable on other client computing platforms that comply with Internet standards. If you experience technical problems that prevent you from viewing the course, we will promptly issue a full refund upon request.