10170 - BAP1 Gene Inactivation/Loss: Relevance to Skin Tumors

Course Director

Steven R. Tahan, M.D., Harvard Medical School


This course is an update on the current understanding of the BAP1 gene, its functional domains, tumor syndromes associated with loss of function germline mutations, and tumors with somatic loss of BAP1 gene expression. It concentrates on cutaneous tumors associated with BAP1 loss, their work-up, and clinical implications.


AMA PRA Category 1 Credits™

Opus Medicus designates this Internet enduring material for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Maintenance of Certification (MOC) Credits

In addition to AMA PRA Category 1 Credits™, Opus Medicus designates this course for Specialty Board MOC Program Credits:

1.0 ABP CC/MOC Credits1

Accreditation Statement

Opus Medicus is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Tuition Fees

Course & Credits: $26.00

Course Dates

Last Review Date: 04-Dec-2020
Expiration Date: 04-Dec-2023


After taking this course, participants are expected to gain knowledge of:

1. BAP1 gene and function of its product.

2. Implications of germline and somatic BAP1 mutations.

3. Cutaneous melanocytic lesions with loss of BAP1.


1. Characteristics of the BAP1 gene and its function.

2. Germline mutations in BAP1 and associated tumor syndrome.

3. Somatic mutations in BAP1 and associated tumors.

4. BAP1 inactivated atypical epithelioid melanocytic tumors.

5. BAP1 inactivated skin tumors and BRAF mutations.

6. Behavior of BAP1-inactivated skin tumors.

7. BAP1 in cellular blue nevi and melanomas mimicking cellular blue nevi.

Specific topics covered in this AMA PRA Categogy 1 Credit™ online CME course include BAP1, Wiesner nevus, BAPOMA, MBAIT, and atypical spitz tumor.

American Board of Medical Specialties (ABMS) / Accreditation Council for Graduate Medical Education (ACGME) Competencies

☑  Patient Care (PC)
☑  Medical Knowledge (MK)

Financial Relationship Disclosure and Content Attestation

Dr. Steven R. Tahan attests that commercial entities with which he has relationships do not offer healthcare related products or services relevant to the content of this course. No other person who has provided content for or who can influence the content of this course has disclosed financial relationships with commercial entities that offer healthcare-related products or services relevant to the course content.

There has been no commercial support for this course.

Supported Computer Hardware and Software Configurations2

Supported client computing platforms include:

A broadband Internet connection is required (e.g., cable, DSL, and 3G or 4G wireless). The course presentation is automatically scaled to the size of the display, from 800x480 pixels (minimum supported) to 1920x1200 pixels. On some smart phones, viewing courses may be tedious.

Supported browsers include:

Javascript, cookies, and popups must be enabled on your browser (which is the default configuration for most browsers).

1. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 CC/MOC credits for the American Board of Pathology (ABP) Continuing Certification (CC) / Maintenance of Certification (MOC) Program, in addition to AMA PRA Category 1 Credits™. Participants will earn CC/MOC credits equivalent to the amount of AMA PRA Category 1 credits claimed for the activity. Immediately upon course completion, Opus Medicus will submit participant completion information to ACCME for the purpose of granting ABP CC/MOC credit.

2. The course may also be viewable on other client computing platforms that comply with Internet standards. If you experience technical problems that prevent you from viewing the course, we will promptly issue a full refund upon request.