10184 - Rare and not-so-rare complications of sickle cell trait and sickle cell disease: two illustrative cases

Course Directors

Andrey Prilutskiy, M.D., Boston University School of Medicine
Reyhan Gedik, M.D., Boston University School of Medicine
Karen Quillen, M.D., Boston University School of Medicine


This course uses a case-based approach to illustrate a rare tumor associated with sickle cell trait and a transfusion complication in sickle cell disease.


AMA PRA Category 1 Credits™

Opus Medicus designates this Internet enduring material for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Maintenance of Certification (MOC) Credits

In addition to AMA PRA Category 1 Credits™, Opus Medicus designates this course for Specialty Board MOC Program Credits:

1.0 ABP CC/MOC Credits1

Accreditation Statement

Opus Medicus is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Tuition Fees

Course & Credits: $26.00

Course Dates

Last Review Date: 14-Nov-2021
Expiration Date: 13-Nov-2024


After taking this course, participants will gain an understanding of:

1. Metastatic carcinoma in a young woman with sickle cell trait.

2. Differential diagnoses of anemia exacerbation in a young man with sickle cell disease.

3. The process of identifying alloantibody specificities in pre-transfusion specimens.

4. Hyperhemolysis syndrome in sickle cell disease.


1. Clinical features of renal medullary carcinoma.

2. Immunohistochemical profile of renal medullary carcinoma.

3. Clinical and serologic features of hyperhemolysis.

Specific topics covered in this AMA PRA Categogy 1 Credit™ online CME course include renal medullary carcinoma, hyperhemolysis, and sickle cell disease.

American Board of Medical Specialties (ABMS) / Accreditation Council for Graduate Medical Education (ACGME) Competencies

☑  Patient Care (PC)
☑  Medical Knowledge (MK)
☑  Practice-Based Learning (PBL)

Financial Relationship Disclosure and Content Attestation

Drs. Karen Quillen, Andrey Prilutskiy, and Reyhan Gedik attest that they have no financial relationships with a commercial entity offering healthcare related products and/or services. Dr. Steven R. Tahan, Education Committee Chair, attests that commercial entities with which he has relationships do not offer healthcare-related products or services relevant to the content of this course. No other person who has provided content for or who can influence the content of this course has disclosed financial relationships with commercial entities that offer healthcare-related products or services relevant to the course content.

There has been no commercial support for this course.

Supported Computer Hardware and Software Configurations2

Supported client computing platforms include:

A broadband Internet connection is required (e.g., cable, DSL, and 3G or 4G wireless). The course presentation is automatically scaled to the size of the display, from 800x480 pixels (minimum supported) to 1920x1200 pixels. On some smart phones, viewing courses may be tedious.

Supported browsers include:

Javascript, cookies, and popups must be enabled on your browser (which is the default configuration for most browsers).

1. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 CC/MOC credits for the American Board of Pathology (ABP) Continuing Certification (CC) / Maintenance of Certification (MOC) Program, in addition to AMA PRA Category 1 Credits™. Participants will earn CC/MOC credits equivalent to the amount of AMA PRA Category 1 credits claimed for the activity. Immediately upon course completion, Opus Medicus will submit participant completion information to ACCME for the purpose of granting ABP CC/MOC credit.

2. The course may also be viewable on other client computing platforms that comply with Internet standards. If you experience technical problems that prevent you from viewing the course, we will promptly issue a full refund upon request.