10246 - Low-Density Lipoprotein Apheresis for Preventing Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation

Course Directors

Michael Moritz, M.D., University of Pittsburgh School of Medicine
Rupesh Raina, M.D.


Nephrotic syndrome can be particularly challenging after renal transplantation. This is because the treatment of nephrotic syndrome involves immunosuppression which transplant patients already have received. Focal Segmental Glomerulosclerosis (FSGS) is the most challenging of the nephrotic syndromes post-transplant. In this course, we will be discussing diagnosis and treatment strategies for recurrent FSGS after kidney transplantation.


AMA PRA Category 1 Credits™

Opus Medicus designates this Internet enduring material for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Maintenance of Certification (MOC) Credits

In addition to AMA PRA Category 1 Credits™, Opus Medicus designates this course for Specialty Board MOC Program Credits:

1.0 ABIM MOC Points1

Accreditation Statement

Opus Medicus is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Tuition Fees

Course & Credits: Free

Course Dates

Offered Date: 26-May-2021
Expiration Date: 25-May-2024


After taking this course, participants will be able to:

1. Describe the effect of hyperlipedemia on chronic progressive glomerular disease and tubulointerstitial injury.

2. List the current techniques of LDL apheresis and identify the most efficacious treatments for removal of LDL and lipoprotein.

3. Explain the mechanisms of action and risks associated with LDL apheresis.


1. The diagnosis of FSGS and the particular challenges associated with this diagnosis.

2. Treatment options for FSGS post transplantation.

3. Importance of adequate and prompt treatment for FSGS.

4. LDL apheresis as a novel therapy for drug-resistant primary FSGS and post renal transplant FSGS reoccurrence.

Specific topics covered in this AMA PRA Categogy 1 Credit™ online CME course include Nephrotic syndrome, Focal Segmental Glomerulosclerosis, FSGS, and post-transplant recurrent FSGS.

American Board of Medical Specialties (ABMS) / Accreditation Council for Graduate Medical Education (ACGME) Competencies

☑  Patient Care (PC)
☑  Medical Knowledge (MK)

Financial Relationship Disclosure and Content Attestation

Dr. Rupesh Raina, course director, attests that he has no financial relationships with a commercial entity providing health-care related products and/or service. Dr. Michael Moritz, moderator, discloses that he has consulted and lectured for Alnylum. He attests that they have had no influence on the course content. Dr. Paul VanderLaan, reviewer, discloses that he has consulted in an advisory capacity for Gala Therapeutics, Caris Life Sciences, Foundation Medicine, Flatiron Health, Intuitive Surgical, and Clearview Healthcare Partners. He attests that none of these entities have had an influence on the course content or his review thereof. Dr. Steven R. Tahan, Education Committee Chair, attests that he has no financial relationships with a commercial entity providing health-care related products and/or service. No other person who has provided content for or who can influence the content of this course has disclosed financial relationships with commercial entities that offer healthcare-related products or services relevant to the course content. Financial support for this course has been received from Kaneka Pharma America, LLC, which has had no influence on the course content.

Supported Computer Hardware and Software Configurations2

Supported client computing platforms include:

A broadband Internet connection is required (e.g., cable, DSL, and 3G or 4G wireless). The course presentation is automatically scaled to the size of the display, from 800x480 pixels (minimum supported) to 1920x1200 pixels. On some smart phones, viewing courses may be tedious.

Supported browsers include:

Javascript, cookies, and popups must be enabled on your browser (which is the default configuration for most browsers).

1. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points for the American Board of Internal Medicine (ABIM) Maintenance of Certification (MOC) Program, in addition to AMA PRA Category 1 Credits™. Participants will earn MOC points equivalent to the amount of AMA PRA Category 1 credits claimed for the activity. Immediately upon course completion, Opus Medicus will submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

2. The course may also be viewable on other client computing platforms that comply with Internet standards. If you experience technical problems that prevent you from viewing the course, we will promptly issue a full refund upon request.