10250 - An Update on Lipoprotein(a) and Lipid-apheresis

Course Directors

Patrick M. Moriarty, M.D., University of Kansas Medical Center
Karol Watson, University of California Los Angeles, David Geffen School of Medicine


Elevated Lp(a) level, which is associated with an increased risk of cardiovascular disease (CVD), is estimated to affect 20%-30% of the world's population. Presently, no medication is approved by the FDA to lower Lp(a) and CVD risk. The future holds promise of newer therapies to lower Lp(a) but until then lipid-apheresis remains the only option for the treatment of elevated Lp(a) and CVD.


AMA PRA Category 1 Credits™

Opus Medicus designates this Internet enduring material for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Maintenance of Certification (MOC) Credits

In addition to AMA PRA Category 1 Credits™, Opus Medicus designates this course for Specialty Board MOC Program Credits:

1.0 ABIM MOC Points1

Accreditation Statement

Opus Medicus is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Tuition Fees

Course & Credits: Free

Course Dates

Offered Date: 17-May-2022
Expiration Date: 16-May-2025


After taking this course, participants will have a greater understanding of:

1. The structure and normal metabolism of lipoprotein(a).

2. The associative risk of cardiovascular disease with elevated LP(a).

3. The prevalence and mechanism of action of elevated Lp(a) levels.

4. Present and potential future therapeutic options for elevated Lp(a).


1. Structure of lipoprotein(a).

2. Relationship between Lp(a) concentration and cardiovascular risk.

3. World prevalence of elevated Lp(a).

4. Effect and mechanism of action of elevated Lp(a).

5. Treatment of elevated Lp(a).

6. Effects of lipid-apheresis.

American Board of Medical Specialties (ABMS) / Accreditation Council for Graduate Medical Education (ACGME) Competencies

☑  Patient Care (PC)
☑  Medical Knowledge (MK)

Financial Relationship Disclosure and Content Attestation

Dr. Patrick Moriarty, course director, discloses that he has received research grants from and consulted for Regeneron, Amgen, Esperion, Kaneka, Stage II Innovations, and Alkahest, received research grants from Novartis, Kowa Pharmaceuticals, Ionis, Aegerion, Vascular Health Foundation, and FH Foundation, consulted for HDL, served on the advisory boards of Norvartis and Vascular Health Foundation, and served on the executive committee of Esperion. He attests that none of these entities have had an influence on the course content. Dr. Karol Watson, moderator, discloses financial relationships with Amari, Amgen, Boehringer Ingelheim, Novartis, and Esperion and attests that they have had no influence on the course content. Dr. Paul VanderLaan, reviewer, discloses that he has consulted in an advisory capacity for Gala Therapeutics, Caris Life Sciences, Foundation Medicine, Flatiron Health, Intuitive Surgical, and Clearview Healthcare Partners. He attests that none of these entities have had an influence on the course content or his review thereof. Dr. Steven R. Tahan, Education Committee Chair, attests that he has no financial relationships with a commercial entity providing health-care related products and/or services. No other person who has provided content for or who can influence the content of this course has disclosed financial relationships with commercial entities that offer healthcare-related products or services relevant to the course content. Financial support for this course has been received from Kaneka Medical America, LLC, which has had no influence on the course content.

Supported Computer Hardware and Software Configurations2

Supported client computing platforms include:

A broadband Internet connection is required (e.g., cable, DSL, and 3G or 4G wireless). The course presentation is automatically scaled to the size of the display, from 800x480 pixels (minimum supported) to 1920x1200 pixels. On some smart phones, viewing courses may be tedious.

Supported browsers include:

Javascript, cookies, and popups must be enabled on your browser (which is the default configuration for most browsers).

1. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points for the American Board of Internal Medicine (ABIM) Maintenance of Certification (MOC) Program, in addition to AMA PRA Category 1 Credits™. Participants will earn MOC points equivalent to the amount of AMA PRA Category 1 credits claimed for the activity. Immediately upon course completion, Opus Medicus will submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

2. The course may also be viewable on other client computing platforms that comply with Internet standards. If you experience technical problems that prevent you from viewing the course, we will promptly issue a full refund upon request.